L-アルギニンはT細胞の代謝を調節し,生存率と抗腫瘍活性を強化する
Roger Geiger1, Jan C Rieckmann2, Tobias Wolf1
1Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona 6500, Switzerland; Institute of Microbiology, ETH Zurich, Zurich 8093, Switzerland.
Cell
|October 18, 2016
まとめ
T細胞のL-アルギニンの増強は,その代謝能力と生存を高め,抗腫瘍活動を促進する. この発見はL-アルギニンが
科学分野:
- 免疫学と代謝
- 細胞生物学
背景:
- T細胞の代謝活動は,その機能と運命を決定する.
- T細胞の活性化後の ダイナミックな代謝変化を理解することが重要です
研究 の 目的:
- 活性化されたヒトのナイブT細胞のダイナミックな代謝体とタンパク質のプロフィールを調査する.
- T細胞の機能と生存におけるL-アルギニンの代謝の役割を調査する.
主な方法:
- ダイナミックメタボロームとプロテオームのプロファイリングのための高解像度の質量スペクトロメトリ.
- T細胞のクローンと マウスモデルを分析して結果を確認する.
主要な成果:
- アルギニンの代謝に重大な変化があり,細胞内L-アルギニンが減少した.
- L-アルギニンの増加により,T細胞の代謝が糖分解から酸化性リン酸化へと変化した.
- L- アルギニンの増加は,中央記憶型のT細胞を活性化させ,生存率と抗腫瘍活性を高めました.
結論:
- 細胞内L-アルギニンのレベルは,T細胞の代謝能力と生存能力に直接影響を与えます.
- L-アルギニン感受性転写レギュレータ (BAZ1B,PSIP1,TSN) が特定されました.
- L-アルギニンの代謝をターゲットにすることは,抗腫瘍T細胞の反応を高めるための潜在的な戦略です.
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