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Updated: Mar 13, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

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GPCRのシグナリングは,構成の変化の波に乗っています

Louis M Luttrell1

  • 1Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA; Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA.

Cell
|October 22, 2016
PubMed
まとめ

どのGタンパク質結合受容体 (GPCR) のシグナル伝達経路が活性化され,どのように機能するのかを,リガンド構造が決定する. この発見により 特定の治療目標に合わせて 薬の効能を決定できます

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