p62 in 癌: 信号アダプタ 自動食症を超えた
Jorge Moscat1, Michael Karin2, Maria T Diaz-Meco1
1Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell
|October 22, 2016
まとめ
Sqstm1によってコードされたアダプタータンパク質p62は,オートファジー以外にも重要な役割を果たします. 主要なシグナル伝達機能を通して,上皮腫瘍の発現とストロマ腫瘍の抑制を独立して調節する.
科学分野:
- 細胞生物学
- 分子腫瘍学
- オートファギーの研究
背景:
- アダプタータンパク質は 選択的オートファジーに不可欠であり 細胞の解毒とストレス管理に不可欠なプロセスです
- タンパク質p62 (Sqstm1) は,オートファジー経路の参加者として知られています.
研究 の 目的:
- セルラーシグナル伝達におけるアダプタタンパク質p62 (Sqstm1) の役割を,自食性から独立して調査する.
- 腫瘍の発症と進行におけるp62の機能を明らかにする.
主な方法:
- この研究には,p62の機能を評価する分子生物学技術が含まれている可能性が高い.
- エピテリア腫瘍の発現とストロマ腫瘍の抑制に関連するシグナル伝達経路の分析が行われました.
主要な成果:
- 新しい証拠は,p62が信号伝達において,自己消化から独立して重要な役割を果たしていることを示している.
- p62は,上皮細胞の腫瘍発現に不可欠です.
- p62は,腫瘍細胞の進行抑制に寄与する.
結論:
- アダプタータンパク質p62 (Sqstm1) は,オートファジーとは独立して重要なシグナル伝達機能を備えている.
- これらの機能は,上皮における腫瘍の発生と,ストロマにおける腫瘍の進行を抑制する上で極めて重要です.
関連する概念動画
mTOR Signaling and Cancer Progression
5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression
1.6K
1.6K
Autophagy
6.0K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
6.0K
Interactions Between Signaling Pathways
7.7K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.7K
The Intrinsic Apoptotic Pathway
9.1K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
9.1K
Adaptive Mechanisms in Cancer Cells
7.3K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.3K


