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Updated: Mar 12, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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NLRP3 炎症ホルモンはアルドステロン誘発の血管損傷を媒介する

Thiago Bruder-Nascimento1, Nathanne S Ferreira2, Camila Z Zanotto2

  • 1From Department of Pharmacology (T.B.-N., N.S.F., C.Z.Z., F.R., I.O.P., V.C.O., K.B.N., R.A.-L., E.C., F.L.M., D.P., J.P.M.L., J.C.A.F., R.C.T.), Department of Physiology (C.A.A.S., R.F.), Department of Biochemistry and Immunology (D.C.), Department of Clinical Medicine, Division of Endocrinology (P.C.E., A.C.M.), and Department of Cell and Molecular Biology (D.S.Z.), Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil (F.V.P., T.B., N.O.); and Department of Pharmacology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil (S.B.C.). bruderthiago@usp.br rtostes@usp.br.

Circulation
|November 3, 2016
PubMed
まとめ

アルドステロンは,主要な炎症経路であるNLRP3炎症体を活性化することで血管損傷を引き起こす. アルドステロンが誘発した血管機能不全を防ぐため,この炎症体を遮断することで,治療目標として示唆される.

キーワード:
アルドステロン免疫学についてインフラマソーム炎症

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