脂肪酸合成は,糖尿病における炎症に対する血の構成
Xiaochao Wei1, Haowei Song1, Li Yin1
1Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Nature
|November 5, 2016
まとめ
マクロファージ脂肪酸合成酵素 (FAS) は,食事によるインスリン抵抗性および炎症に不可欠です. マクロファージのFASを阻害すると,膜の組成とシグナル伝達経路を変えることで,これらの状態を防ぐことができます.
科学分野:
- 免疫学
- 代謝 疾患
- 細胞生物学
背景:
- 食物脂肪は慢性的な炎症によって インスリン抵抗性を引き起こす
- マクロファージ由来の炎症性タンパク質が この過程に影響します
- 栄養価の高い食事が糖尿病の発症に 与える影響は不明である.
研究 の 目的:
- ダイエットによるインスリン抵抗性におけるマクロファージの内生脂肪酸合成の役割を調査する.
- マクロファージ脂肪酸合成酵素 (FAS) が炎症と代謝機能障害に及ぼす影響を決定する.
主な方法:
- マクロファージでFasn遺伝子が削除されたマウスを使用した.
- 膜の組成,コレステロールの保持,およびRho GTPaseの取引の分析
- 炎症信号とインスリン抵抗性の評価
主要な成果:
- 食事によるインスリン抵抗性,脂肪組織の炎症,およびマクロファージの増殖を予防した.
- FAS欠乏症は膜の秩序とコレステロール保持を変化させ,Rho GTPaseの輸送を妨害した.
- 外因的なコレステロールが 炎症信号を救ったのです
結論:
- 食中の脂肪によって引き起こされるインスリン抵抗性の発達には,マクロファージの内生脂肪酸の生成が不可欠である.
- マクロファージのFASNは,コレステロールに依存するシグナル伝達ネットワークを誘導するプラズマ膜環境を作り出します.
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