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Loss of Tumor Suppressor Gene Functions01:12

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
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Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
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Genetic Screen for Identification of Multicopy Suppressors in Schizosaccharomyces pombe
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遺伝子抑制の相互作用を世界規模で調査する

Jolanda van Leeuwen1, Carles Pons2,3, Joseph C Mellor1,4

  • 1Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada.

Science (New York, N.Y.)
|November 5, 2016
PubMed
まとめ
この要約は機械生成です。

遺伝子の抑制は 遺伝子の変異の欠陥を救います 研究者は酵母遺伝子の相互作用をマッピングし 新しい細胞経路を明らかにし 人口増加に影響を与える二次変異を特定しました

さらに関連する動画

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A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
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科学分野:

  • 遺伝学
  • システム生物学
  • 分子生物学

背景:

  • 遺伝抑制は,ある遺伝子の突然変異が,別の遺伝子の突然変異によって引き起こされる現象的欠陥を救済する現象である.
  • 遺伝子抑制を理解することで 遺伝子機能や細胞ネットワークの洞察が得られます

研究 の 目的:

  • 大規模な抑制ネットワークを構築することで 遺伝子抑制の原理を探求する.
  • 新しい遺伝子関係を特定し,遺伝子抑制の背後にあるメカニズムを理解する.

主な方法:

  • 既知の抑制ペアの文献整理
  • 系統的な遺伝子マッピングと全ゲノムシーケンシングを含む偏見のない実験データの分析.
  • 酵母菌における包括的な抑制ネットワークの構築

主要な成果:

  • 抑制ペアを通して,機能的に関連した遺伝子の間の数多くの新しい関係を特定した.
  • 酵母菌で大規模な 遺伝子抑制ネットワークを作り出しました
  • 静止相を遅らせる特定の遺伝子の二次変異を発見し,その増殖を促した.

結論:

  • この研究は,細胞経路の機能的組織に関する新しい洞察を提供します.
  • 遺伝子抑制の一般的なメカニズムを理解するための定量的な枠組みを提供する.
  • 特定された二次変異は,遺伝的変異への反応として,集団の動態に影響を与える新しいメカニズムを強調しています.