個々のヒトのサイトカイン反応に影響を与える宿主および環境要因
Rob Ter Horst1, Martin Jaeger1, Sanne P Smeekens1
1Department of Internal Medicine and Radboudumc Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Gelderland 6500HB, the Netherlands.
Cell
|November 5, 2016
まとめ
年齢,性別,季節性などの環境要因は ヒトの免疫反応に大きく影響し サイトカインの産生に影響します アルファ-1-アンチトリプシンレベルは 季節的な免疫変動を部分的に説明しますが,ビタミンDは
科学分野:
- 人間の機能ゲノミクス
- 免疫学
- 環境 健康
背景:
- 免疫媒介疾患は,免疫反応の変動から生じる.
- ヒトの免疫変動に影響を与える要因を理解することは極めて重要です.
研究 の 目的:
- 非遺伝的宿主因子と環境の影響がヒトのサイトカイン反応に及ぼす影響を調査する.
- これらの因子,循環媒介体,およびサイトカインの産生との関連を分析する.
主な方法:
- 534人の健康な被験者のサイトカイン生成と循環媒体の分析
- 19種類の微生物と非微生物を刺激しました
- 環境要因 (季節性,年齢,性別) と宿主遺伝子の評価
主要な成果:
- 年齢や性別などの非遺伝的要因は,サイトカインの産生と媒介者のレベルに強い影響を及ぼします.
- 年間季節性は,サイトカイン反応に影響を与える重要な環境要因です.
- アルファ-1-アンチトリプシンは季節性を部分的に媒介し,ビタミンDの効果は限られている.
結論:
- 非遺伝的な宿主要因と環境の季節性は,ヒトの免疫反応の変動性を決定する重要な要因である.
- 免疫メディエーターに対する季節性の影響は,アルファ-1-アンチトリプシンによって部分的に説明されます.
- 公開されているデータは,将来の免疫学的研究のためのリソースを提供します.
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