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Updated: Mar 12, 2026

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骨髄細胞におけるPI3Kγを標的としたチェックポイント阻害療法に対する抵抗の克服

Olivier De Henau1, Matthew Rausch2, David Winkler2

  • 1Memorial Sloan Kettering Cancer Center, Parker Institute for Cancer Immunotherapy and Swim Across America/Ludwig Collaborative Laboratory, New York, New York 10065, USA.

Nature
|November 10, 2016
PubMed
まとめ

PI3Kγ阻害剤で骨髄細胞を標的にすると,がんの免疫療法に対する抵抗を克服できます. このアプローチは腫瘍の免疫マイクロ環境を再構成し,免疫チェックポイントを阻害する抗体に対する感受性を回復させます.

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