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Updated: Mar 12, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation

Published on: May 20, 2020

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NMRによって明らかにされた原生膜におけるEGFRダイナミクスの変化

Mohammed Kaplan1, Siddarth Narasimhan1, Cecilia de Heus2

  • 1NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, 3584 CH Utrecht, the Netherlands.

Cell
|November 15, 2016
PubMed
まとめ

Epidermal 成長因子受容体 (EGFR) の活性化には,動的変化が伴う. EGFRへのリガンド結合は,運動を制限し,抗がん治療に不可欠な受容体二酸化とキナーゼ活性化を促進する.

キーワード:
EGFRNMR について固体NMRアクティベーション癌について膜タンパク質レセプタータイロシンキナーゼ

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