予期的な不安の神経解剖学的相関関係
E M Reiman1, M J Fusselman, P T Fox
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
まとめ
予期的な不安は正常な感情ですが,脳の臨界極の血流が増加しました. これらの発見は,一時極の活動と正常的および病的な不安状態の両方を関連付けています.
科学分野:
- 神経科学は神経科学である.
- 精神科医は精神病を患っている.
- メディカルイマージング (医学イメージング)
背景:
- 不安は複雑な神経生物学的な基盤を持つ一般的な人間の感情です.
- 不安の神経基盤を理解することは,効果的な治療法の開発に不可欠です.
- 以前の研究では,さまざまな脳の領域が不安反応に関与していることが示された.
研究 の 目的:
- 正常な予期的な不安の神経解剖学的相関性を調査するために.
- 不安時のニューロン活動の変化を示す脳領域を特定する.
- 正常的および病理的な不安の両方における特定の脳領域の役割を調査する.
主な方法:
- 地域脳血流量 (rCBF) を測定するためにポジトロン放出トモグラフィ (PET) を利用しました.
- 健康なボランティアで痛ましい電気ショックを予期する前,その間,そしてその後のrCBFを評価した.
- 血流の変化は,主観的な不安の経験と相関しています.
主要な成果:
- 予期的な不安の間,双極の時極で血流の有意な増加が観察されました.
- これらの時極領域は以前,パニック障害の患者における乳酸誘発的不安に関与していた.
- テンプルポール活動と不安の経験との関連が示された.
結論:
- 側頭葉は,正常な人間の不安の神経生物学に関与する重要な脳領域です.
- 発見は,正常な予期的な不安と病的な不安状態のための共通の神経解剖学的基板を示唆しています.
- 適応的および不適応的不安反応の両方において,一時極の役割を強調しています.
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