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Updated: Mar 12, 2026

Application of Stopped-flow Kinetics Methods to Investigate the Mechanism of Action of a DNA Repair Protein
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Application of Stopped-flow Kinetics Methods to Investigate the Mechanism of Action of a DNA Repair Protein

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カスケード式MutSとMutLのスライディングクランプは,不一致修復を活性化するためにDNA拡散を制御します

Jiaquan Liu1, Jeungphill Hanne1, Brooke M Britton1

  • 1Department of Cancer Biology and Genetics, The Ohio State University Wexner Medical Center, Columbus, Ohio 43210, USA.

Nature
|November 17, 2016
PubMed
まとめ

MutSとMutLのDNA不一致修復タンパク質は DNAに安定したスライディングクランプを形成する. このメカニズムは,効率的なDNA修復を可能にし,連続的なクランプアセンブリを強調して,MutHエンドヌクレアスの募集を容易にする.

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