サクラル自律流出は共感性である

I Espinosa-Medina¹, O Saha¹, F Boismoreau¹

¹Institut de Biologie de l'École Normale Supérieure (IBENS), INSERM, CNRS, École Normale Supérieure, Paris Sciences et Lettres Research University, Paris, 75005 France.

Science (New York, N.Y.)

|November 19, 2016

まとめ

長い間副交感性と考えられてきた交感性神経系と共通する特徴がありますこの発見は自律神経系を再定義します

科学分野:

神経科学
発達生物学
進化生物学

背景:

自律神経系 (ANS) は,伝統的に頭蓋骨のパラシンパティックと胸椎のシンパティック流出に分かれています.
排泄や排尿などの機能を制御する骨盤内臓神経は副交感性として分類され,サクラル神経から発生する.

研究の目的:

自律神経系内のサクラアウトフローニューロンの分類を再評価する.
ネズミの頭蓋骨とサクラルの流出の表型とオントジェネティックな特徴を調査する.

主な方法:

15のフェノタイプとオントジェネティック特性の比較分析
頭蓋のパラシンパティックと胸のシンパティックアウトフローの前および後ギャングリオンニューロンを区別する.
既定の基準に基づいてサクラ流出を評価する.

主要な成果:

サクラ外流ニューロンは,すべての15の特徴に基づいて,胸交感ニューロンと区別できませんでした.
頭蓋骨の外流ニューロンは胸頸部ニューロンと異なる特徴を示した.
これは純粋に副交感性神経という百年の古い分類に挑戦しています

結論:

自律神経系は双部構造で,頭蓋骨神経はパラシンパシー機能のみ,脊髄神経 (胸部からサクラル) はシンパシー機能のみを有する.
骨盤神経生理学,自律的発達,進化に関する新しい洞察を提供しています.

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