主要な弁動脈と冠動脈の合併手術後の死亡のリスク要因
J K Kirklin1, D C Naftel, E H Blackstone
1Department of Surgery, University of Alabama, Birmingham Medical Center.
Circulation
|June 1, 1989
まとめ
結合弁と冠動脈バイパス移植手術 (CABG) の後の死亡のリスク要因を特定することは極めて重要です. 高齢化,不安定性,特定の弁/動脈疾患により,CABG患者の死亡リスクが増加します.
科学分野:
- 心血管外科手術についてです.
- 心臓外科手術の結果について
- バルブ性心疾患 バルブ性心疾患とは
- 冠動脈疾患 冠動脈疾患 冠動脈疾患
背景:
- 結合弁動脈と冠動脈バイパス移植手術 (CABG) は,ユニークな課題を提示しています.
- 死亡率の危険因子を理解することは,患者の階層化と改善された結果のために不可欠です.
- 以前の分析では任意の分層が用いられ,比較精度が制限されていた可能性がある.
研究 の 目的:
- ミトラル弁 (MV) または大動脈弁 (AV) の外科手術とCABGを併せて受けている患者の死亡のリスク要因を調べる.
- 予後が好ましいか不好ましい患者のサブセットを特定する.
- 手術結果を比較する際の多変量分析を提唱する.
主な方法:
- CABG (1986-1988) を併用した孤立したMVまたはAV手術を受けた141人の患者の遡及的分析.
- アクチュアル生存分析が行われました.
- 年齢,血液動力学的状態,特定の心臓病などの死亡リスク要因が特定され,分析されました.
主要な成果:
- 1ヶ月の生存率は92%で,1年生存率は79%でした.
- 死亡リスクは,手術直後に最も高く,約4ヶ月で減少しました.
- 死因の重要なリスク要因には,高齢化,手術前の血液動力学的不安定性,左主冠動脈疾患,心筋弁不全症,三管不全症,およびより長い心筋不全時間が含まれています.
- 血液動力学的不安定性の高齢患者 (≥70歳) は,30日間の死亡率は20%であった.
- 有利なリスクグループ (70歳未満,左主筋狭窄症なし,血液動力学的安定性,不全性MV疾患なし) は30日間の死亡率<5%でした.
結論:
- 高齢化,血液動力学的不安定性,左側主冠動脈疾患,心筋弁不全症,三管不全症,長期の心筋不全症は,結合弁とCABGによる死亡の重要な危険因子である.
- 高齢者および血液動力学的に不安定な患者は,高リスクサブグループです.
- 連続変数を用いた多変量分析は,異なる患者サブセットにおける手術結果の正確な比較のために推奨されます.
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