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Updated: Mar 11, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
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An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

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ヒトの血液細胞特性の変異と一般的な複雑な疾患との関連

William J Astle1, Heather Elding2, Tao Jiang3

  • 1Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; National Health Service (NHS) Blood and Transplant, Cambridge Biomedical Campus, Long Road, Cambridge CB2 0PT, UK; Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge Biomedical Campus, Forvie Site, Robinson Way, Cambridge CB2 0SR, UK; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge CB1 8RN, UK.

Cell
|November 19, 2016
PubMed
まとめ

この研究は,大規模なゲノム分析を使用して,血液細胞の特徴に影響を与える珍しい遺伝的変異を特定しました. 血液細胞の性質と 自己免疫疾患や心臓病などの 共通の遺伝的経路を明らかにします

キーワード:
メンデルのランダム化自己免疫疾患血について心血管疾患複雑な病気エピジェネティクス遺伝子について血液学ヘマトポエシス

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