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関連する概念動画

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

10.1K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
10.1K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.3K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
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Introduction to Innate and Adaptive Immunity01:21

Introduction to Innate and Adaptive Immunity

11.0K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
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Immunological Memory01:23

Immunological Memory

17.6K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
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関連する実験動画

Updated: Mar 11, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

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24時間 免責権

Kevin Man1, Andrew Loudon2, Ajay Chawla3,4

  • 1Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA.

Science (New York, N.Y.)
|November 26, 2016
PubMed
まとめ
この要約は機械生成です。

身体の免疫システムは 日常時計によって制御され 免疫防御と有害な過剰活性化のリスクをバランスとします この関連性を理解することで 炎症性疾患や感染症の 新しい治療法が生まれます

さらに関連する動画

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Quantitative Measurement of the Immune Response and Sleep in Drosophila
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Quantitative Measurement of the Immune Response and Sleep in Drosophila

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関連する実験動画

Last Updated: Mar 11, 2026

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

8.0K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.9K
Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.1K

科学分野:

  • 免疫学
  • クロノバイオロジー
  • システム生物学

背景:

  • 免疫は重要な防御メカニズムですが 過剰に活性化すると病変を引き起こす可能性があります
  • 免疫系の機能は 日常時計の影響で 日常リズムを示します
  • 免疫コストと利益のバランスには 重要な役割を果たします

研究 の 目的:

  • 免疫反応を調節する 昼夜時計の役割を探る
  • 免疫を制御する環境と 内部生物学的時計の相互作用を理解する
  • 免疫関連疾患の潜在的治療標的を特定する

主な方法:

  • シルカディアンオシレータと免疫細胞の機能を結びつける分子メカニズムの調査.
  • 免疫のパラメータに対する昼夜リズムの影響を分析する.
  • 免疫調節における外部環境信号と内部時計の相互作用を検証する.

主要な成果:

  • 日常時計のメカニズムは 免疫系の調節に不可欠です
  • 環境のシグナルと 細胞内振動器の相互作用により 免疫反応は周期的に最適化されます
  • リズム的な免疫パラメータは,昼夜時計の機能の重要な特徴です.

結論:

  • 免疫反応を最適化し 身体のフィットネスを高めます
  • 時計制御による免疫調節経路の解明は,新しい治療戦略を明らかにするかもしれません.
  • サーカディアンメカニズムをターゲットにすると 感染症や炎症性疾患の治療に 新たなアプローチが生まれます