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副作用のバイオマーカーとしてのアゴニスティック・アニオテンシン受容体自己抗体の発見と検証

  • 0From Biology of Healthy Aging Program, Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University, Baltimore, MD (P.M.A., A.A.J., L.J.P., Q.-L.X., J.D.W., N.S.F.); Center on Aging and Health, Johns Hopkins University, Baltimore, MD (P.M.A., Q.-L.X., J.D.W., N.S.F.); Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD (J.T.); Departments of Medicine and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD (R.G.H.); and Rush Institute on Healthy Aging, Rush University Medical Center, Chicago, IL (D.A.B.).
Circulation +

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2016年12月2日

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2016年12月2日

PubMedで要約を見る

まとめ

この要約は機械生成です。

アニオテンシンII型1受容体自己抗体 (AT1RaAbs) は,高齢者の炎症,高血圧,有害な健康結果と相関しています. 血管新生受容体ブロッカーの治療は,これらのリスクを軽減し,患者のアウトカムを改善することができます.

科学分野

  • 心血管研究
  • 免疫学
  • ゲロントロジー

背景

  • アニオテンシンII型1受容体自己抗体 (AT1RaAbs) は,機能的測定値や有害な健康結果と明確に関連していない.
  • AT1RaAbsは患者のリスクを分層化し,血管新生素受容体阻害剤 (ARB) 治療の候補者を特定する可能性があります.

研究 の 目的

  • コミュニティに住む成人のAT1RaAbsと機能的な測定値と有害な健康結果との関連を調査する.
  • 高いAT1RaAbレベルを有する個体における結果に対するARB治療の影響を調査する.

主な方法

  • ボルチモアの発見コホート (N=255) とシカゴの検証コホート (N=60) を分析した.
  • 人口統計,生理学的データ,身体機能検査,健康の結果を評価した.
  • ARB治療の効果を含むAT1RaAbsとアウトカムとの関連が調査されました.

主要な成果

  • 高いAT1RaAbsは,炎症 (IL-6),高血圧,高いBMI,弱い握り力,そして遅い歩行速度と相関しています.
  • 高いAT1RaAbsは,転倒,脆弱性,および死亡率の増加と関連していました.
  • シカゴのコホートでは,AT1RaAbsは転倒と相関し,死亡までの時間を短縮しました.
  • ARB治療は,血圧の改善と,握り力の低下と生存率の低下と関連していました.

結論

  • 高齢者のAT1RaAbレベルは,炎症,高血圧,有害な健康結果と関連しています.
  • ARB治療は高レベルのAT1RaAbの悪影響を軽減する可能性がある.

キーワード:

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