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Updated: Mar 11, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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河馬経路キナーゼ LATS1/2 ががん免疫を抑制する

Toshiro Moroishi1, Tomoko Hayashi2, Wei-Wei Pan3

  • 1Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|December 3, 2016
PubMed
まとめ

ヒッポの経路,特に大きな腫瘍抑制剤1と2 (LATS1/2) キナーゼは,予期せぬ形で抗腫瘍免疫を抑制する. LATS1/ 2を阻害すると,免疫反応が強化され,腫瘍の収縮とがんワクチンの有効性が改善されます.

キーワード:
B16 メラノーマ海馬LATS についてTAZ についてトール型受容体YAP についてがんに対する免疫エクソソーム免疫療法インターフェロン

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