関連する実験動画

Updated: Mar 10, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
07:41

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

Published on: February 20, 2018

9.6K

CCR9受容体の細胞内アロステル抗作用

Christine Oswald1, Mathieu Rappas1, James Kean1

  • 1Heptares Therapeutics Ltd, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire AL7 3AX, UK.

Nature
|December 8, 2016
PubMed
まとめ

ヴェルシルノンに結合するCCケモカイン受容体タイプ9 (CCR9) の結晶構造は,アロステル対抗メカニズムを示している. この発見は,以前の薬効性問題を説明し,ケモカイン受容体の薬剤設計のための新しいターゲットを提供します.

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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

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SorLA and CLC:CLF-1-dependent Downregulation of CNTFRα as Demonstrated by Western Blotting, Inhibition of Lysosomal Enzymes, and Immunocytochemistry10:16

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Allosteric Regulation01:08

Allosteric Regulation

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Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
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