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Updated: Mar 10, 2026

On-Chip Endothelial Inflammatory Phenotyping
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インテグリン-YAP/TAZ-JNKカスケードは,一方的な切断フローのアテロプロテクティブ効果を媒介する

Li Wang1,2, Jiang-Yun Luo1,2, Bochuan Li3,4

  • 1Institute of Vascular Medicine, Shenzhen Research Institute and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.

Nature
|December 8, 2016
PubMed
まとめ

内皮のYAP/TAZ活動は血流によって調節され,阻害によって炎症と動脈硬化が軽減されます. インテグリン-Gα13-RhoA-YAP経路をターゲットにすることで,動脈硬化症の新たな治療戦略が提供されます.

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