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HER2陽性乳がん

Sibylle Loibl¹, Luca Gianni²

¹German Breast Group, c/o GB Forschungs GmbH, Neu-Isenburg, Germany.

Lancet (London, England)

|December 13, 2016

まとめ

抗HER2治療はHER2陽性乳がんの治療に変化をもたらし,生存率と病理学的完全応答率を向上させました. この病気による持続的な死亡率のため,研究を継続することが不可欠です.

科学分野:

腫瘍学
医学研究

背景:

HER2陽性乳がんは臨床的に重要な課題です.
治療パラダイムに革命を起こしました治療パラダイムに革命を起こしました

研究の目的:

HER2陽性乳がんの治療における重要な進歩をレビューする.
患者に対する抗HER2治療の影響を強調する.

主な方法:

HER2陽性乳がんの臨床データと治療結果のレビュー
ネオアジュバントとアジュバント治療の研究の分析

主要な成果:

ペルツズマブとトラストズマブは,ネオアジュバントの設定でより高い病理学的完全応答率を示した.
併用療法で観察されたイベントフリー生存率の改善.
転移性HER2陽性乳がんの生存率は5年近くである.

結論:

抗HER2治療はHER2陽性乳がんの予後を大幅に改善しました.
進歩にもかかわらず死亡率を下げるためには新しい治療法に関する研究が継続されることが重要です

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