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Improving Translational Accuracy02:07

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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計算方法の再現性を向上させる

Victoria Stodden1, Marcia McNutt2, David H Bailey3

  • 1University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA. vcs@stodden.net.

Science (New York, N.Y.)
|December 13, 2016
PubMed
まとめ

No abstract available in PubMed .

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