中脳ドーパミンニューロンは 時間の判断を制御する
Sofia Soares1, Bassam V Atallah2, Joseph J Paton2
1Champalimaud Research, Champalimaud Centre for the Unknown, Lisbon, Portugal.
まとめ
中脳にあるドーパミンニューロンは 時間の知覚に直接影響します このドーパミンのニューロンを操作することで
科学分野:
- 神経科学
- 認知科学
- クロノバイオロジー
背景:
- 主観的な時間認識は 感情的・認知的な状態によって異なります
- 中脳ドーパミンのニューロンは 時間の見積もりに関与すると考えられています
- ドーパミンのニューロン活動と時間的な判断の間の直接的な因果関係は確立されていません.
研究 の 目的:
- 中脳ドーパミンニューロンの因果関係を調べるため
- ドーパミンのニューロンの活動が 時間の判断に影響するかどうか
主な方法:
- マウスのドーパミン神経細胞の 活動を操作する薬剤遺伝的技術
- 持続時間判断のタスクにおける時間間隔に対する行動感を測定した.
- ドーパミンニューロンの活動が記録され,時間的な推定値と関連して分析された.
主要な成果:
- ドーパミンニューロンの抑制により 時間の持続に対する行動感が低下しました
- ドーパミンニューロンの活動は,試験から試験への時間推定の変動と相関していた.
- ドーパミンニューロンの一時的な活性化や抑制は 時間の推定速度を直接変えました
結論:
- 中脳ドーパミンニューロンの活動は 時間の知覚の重要な要素です
- ドーパミンニューロンは 時間の主観的な体験を 反映するだけでなく 原因も制御します
- これらの発見は 時間の認知における ドーパミンの役割の直接的な証拠を提供する.
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