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Updated: Mar 10, 2026

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
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エヴォロキュマブとアトルバスタチンの脂質タンパク質代謝に対する因数学的効果

Gerald F Watts1, Dick C Chan2, Ricardo Dent2

  • 1From Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, Australia (G.F.W.); School of Medicine and Pharmacology, University of Western Australia, Crawley (D.C.C., S.B., P.H.R.B.); Amgen Europe, Inc, Zug, Switzerland (R.D., R.S., S.M.W.); and Amgen Inc, Thousand Oaks, CA (R. Scott). gerald.watts@uwa.edu.au.

Circulation
|December 13, 2016
PubMed
まとめ

エボロキュマブはPCSK9のモノクローナル抗体で,脂質タンパク質の分解を増加させ,生成を減少させることで,LDLコレステロールを低下させる. アトルバスタチンとの併用療法では,単独療法よりもLDLの減少が顕著で,代謝効果が顕著であった.

キーワード:
AMG 145 についてアトルバスタチンカルシウムリポタンパク質メタボリズム

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