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Updated: Mar 10, 2026

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

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代謝的に不安定なフーマレートエステルは,不可逆的な阻害剤に運動的選択性を与える

Balyn W Zaro1, Landon R Whitby1, Kenneth M Lum1

  • 1The Skaggs Institute for Chemical Biology and Department of Chemical Physiology , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

Journal of the American Chemical Society
|December 15, 2016
PubMed
まとめ

研究者らは,代謝が不安定になるようにすることで,電性薬の精度を向上させる戦略を開発しました. このアプローチは運動的選択性を高め,化学的探査と治療法を改善するために標的型タンパク質の修正を可能にします.

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