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NAD⁺はヒドリドナーおよび減量剤として

Yamin Htet, Andrew G Tennyson¹

¹Center for Optical Materials Science and Engineering Technologies , Anderson, South Carolina 29625, United States.

Journal of the American Chemical Society

|December 15, 2016

まとめ

酸化したニコチナミドアデニン・ディヌクレオチド (NAD+) は,現在還元剤として作用し,ルテニウム・ヒドリドの中間物質を生成する. この発見により潜在的な抗癌療法用の過剰酸化水素の生産が可能になります

科学分野:

カタリシス
バイオ有機化学
生物化学

背景:

還元されたニコチナミドアデニンジヌクレオチド (NADH) は,O2をH2O2に還元するためのルテニウムヒドリド中間物質を生成し,抗癌特性を有する.
酸化ニコチナミドアデニン・ディヌクレオチド (NAD+) をH源として利用すると,より豊富なH2O2の生成が著しく増加する可能性があります.

研究の目的:

NAD+が減量剤とHドナーとして機能することを示すために.
NAD+を用いたRu-H中間生成のメカニズムを調査する.
癌治療と生物学的経路における潜在的な応用を探求する.

主な方法:

還元剤としてのNAD+を試験するために,ABTS•−からABTS−への触媒的還元を使用した.
ルテニウム水化物の中間物質の形成を明らかにするために,メカニズム研究が行われました.

主要な成果:

NAD+は減少剤として効果的に機能することが示された.
証拠は,NAD+からβ-ヒドリドの除去によるRu-H中間物の形成を示唆している.
この経路は,NADHの使用と比較して,かなり大きなH2O2の生産を可能にします.

結論:

NAD+は還元剤とHドナーとして機能し,既知の生物学的還元化学の範囲を広げることができます.
この発見は,新しい生物学的炭水化物の酸化経路を明らかにするかもしれない.
この研究は新しい化学療法戦略を開発するための道を開きます.

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