内部ストレス相互作用によるDNAベースのヒドロゲル形状の可逆調節

Yuwei Hu¹, Jason S Kahn¹, Weiwei Guo¹

¹Institute of Chemistry and The Center for Nanoscience and Nanotechnology and ‡The Fritz Haber Research Center, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.

Journal of the American Chemical Society

|December 15, 2016

まとめ

研究者らは不対称なハイブリッドDNAヒドロゲルを開発し刺激に反応して形を変えましたこれらの形状変化ヒドロゲルは調節可能な硬さと可逆性のある曲げを備えておりスマートデバイスでの応用が可能です

科学分野:

材料科学
バイオテクノロジー
ポリマー化学

背景:

ハイドロゲルは調節可能な性質を持つ多用途な材料です
刺激に反応する材料は物質の行動にダイナミックな制御を提供します
アシンメトリックなデザインは複雑な形状の移行を誘導します

研究の目的:

アシンメトリックな2層のハイブリッドDNAヒドロゲルを組み立てます
リバーシブルな形状の変容を刺激で示すために
レスポンシブなデバイスのアプリケーションを探求する.

主な方法:

層選択的刺激反応の要素を持つ非対称な水素ガスの設計.
様々なトリガー (熱,pH,イオン,化学,生物触媒) を適用して,ヒドロゲルの硬さを調節する.
曲げと材料の性質を相関させる理論モデルの開発.

主要な成果:

DNAヒドロゲルの組み立てに成功しました
複数の刺激によって引き起こされる可逆的な曲げと形の変化の実証.
ハイドロゲル曲線の予測のための理論モデルの検証.

結論:

非対称なハイブリッドDNAヒドロゲルは制御された形状の変化を呈する.
様々なトリガーを介して調整可能な硬さは,正確な形状の調節を可能にします.
潜在的な用途には,バルブ,アクチュエータ,センサー,および薬物投与システムが含まれます.

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