ドロソフィラセグメントのポラリティ遺伝子がパッチしたタンパク質で,いくつかの可能な膜横断ドメインがコードされている
Y Nakano1, I Guerrero, A Hidalgo
1ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.
Nature
|October 12, 1989
まとめ
パッチされた遺伝子は,昆虫のセグメントパターニングに不可欠であり,発達中の細胞通信に関与する大きな膜に及ぶタンパク質をコーディングします.
科学分野:
- 発達生物学 発達生物学とは
- 遺伝学 遺伝学とは
- 分子生物学は分子生物学である.
背景:
- 昆虫のセグメントパターニングは,細胞間通信に依存しています.
- ドロソフィラのセグメント極性遺伝子は,このプロセスを媒介する.
研究 の 目的:
- セグメント極性遺伝子を分子的に特徴付けるには,パッチ.
- 昆虫の胚形成におけるパッチの役割を理解するために.
主な方法:
- パッチされた遺伝子の分子特性.
- 胚形成中のパッチされた遺伝子発現パターンの分析.
主要な成果:
- 修正された遺伝子は,大きなタンパク質をコードする.
- このタンパク質には,複数の潜在的膜を横断するドメインが特徴です.
- パッチは,胚の発達における複雑な発現パターンを示しています.
結論:
- パッチされた遺伝子製品は,昆虫のセグメントの極性を支配する細胞通信ネットワークの重要な構成要素です.
- その構造は,トランスメブラン信号伝達または輸送における役割を示唆しています.
- パッチされた表現を理解することは,発達パターンメカニズムの解読に不可欠です.
さらに関連する動画
関連する概念動画
Conservation of Protein Domains Over Different Proteins
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Position-effect Variegation
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
Polytene Chromosomes
Polytene chromosomes are giant interphase chromosomes with several DNA strands placed side by side. They were discovered in the year 1881 by Balbiani in salivary glands, intestine, muscles, malpighian tubules, and hypoderm of larvae Chironomus plumosus. Hence, these are also called "Salivary gland chromosomes." These are found in insects of the order Diptera and Collembola; in certain organs of mammals; and synergids, antipodes of flowering plants. Polytene chromosomes are also regularly...
The Ratio of X Chromosome to Autosomes
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Hedgehog Signaling Pathway
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Insertion of Multi-pass Transmembrane Proteins in the RER
The rough ER membrane synthesizes, assembles, and embeds transmembrane proteins in diverse topologies. These proteins function as transporters or channels and can remain in the ER membrane or are sent to the Golgi complex, lysosome, and cell membrane.
The multipass transmembrane proteins are the type IV integral membrane proteins with multiple topogenic sequences determining their spatial arrangement in the ER membrane. Nearly all multipass proteins lack a cleavable signal sequence and use...
The multipass transmembrane proteins are the type IV integral membrane proteins with multiple topogenic sequences determining their spatial arrangement in the ER membrane. Nearly all multipass proteins lack a cleavable signal sequence and use...


