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Updated: Mar 10, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

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C. elegans とがんにおけるメトホルミンの成長阻害のための古代の統一メカニズム

Lianfeng Wu1, Ben Zhou1, Noriko Oshiro-Rapley2

  • 1Department of Medicine, Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Cell
|December 17, 2016
PubMed
まとめ

メトフォーミンは,核孔複合体 (NPC) とアシル- コア脱水素酵素家族10 (ACAD10) に影響を及ぼし,癌細胞の成長を抑制し,寿命を延長します. この保存された経路は 癌の新たな治療目標を示しています

キーワード:
ACAD10 についてC. エレガンスメトホルミンNPC についてラグC GTPーゼアシル-コア脱水素酵素家族10癌について糖尿病成長する寿命mTORC1についてラパミシン複合体の機械的標的1ミトコンドリアの呼吸能力核孔複合体原子力輸送

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