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Updated: Feb 7, 2026

GPI Anchoring of Proteins in the ER Membrane
01:29

GPI Anchoring of Proteins in the ER Membrane

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GATA4変異の疾患モデルは,ヒトの心臓形成における転写因子の協力性を明らかにする

Yen-Sin Ang1, Renee N Rivas1, Alexandre J S Ribeiro2

  • 1Gladstone Institute of Cardiovascular Disease and Roddenberry Center for Stem Cell Biology and Medicine, San Francisco, CA 94158, USA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|December 17, 2016
PubMed
まとめ

GATA4遺伝子の変異は心臓細胞の機能を損なっており,遺伝子の調節を妨害し,心臓の欠陥を引き起こす. この研究は,転写因子の変異がタンパク質の相互作用とDNA結合に 影響を及ぼすことによって,どのように病気を引き起こすかを明らかにしています.

キーワード:
GATA4 についてTBX5 について生まれつきの欠陥心筋病心臓の先天性欠陥病気モデリングエピジェネティクス遺伝子調節心臓の発達システム生物学

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