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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
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Constructing Cyclic Peptides Using an On-Tether Sulfonium Center

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ストレント・サイクリック・ディスルフィードは,トランスファーリン受容体と反応して細胞の吸収を可能にします

Daniel Abegg1, Giulio Gasparini1, Dominic G Hoch1

  • 1School of Chemistry and Biochemistry, National Centre of Competence in Research (NCCR) Chemical Biology, University of Geneva , CH-1211 Geneva, Switzerland.

Journal of the American Chemical Society
|December 22, 2016
PubMed
まとめ

新しいアスパラガス酸タグ (AspAタグ) は,保護されていないペプチドの効率的な細胞吸収を可能にします. この方法は,癌細胞にペプチドを送り込み,トランスファーリン受容体ターゲットを介してアポトーシスを誘導します.

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