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Updated: Mar 9, 2026

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
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A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

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5'キャップのm6Amの可逆メチル化はmRNAの安定性を制御する

Jan Mauer1, Xiaobing Luo2, Alexandre Blanjoie3

  • 1Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.

Nature
|December 22, 2016
PubMed
まとめ

mRNAの5'端のN6,2'- O- ディメチラデノシン (m6Am) 変異は,切断に抵抗することで,転写の安定性を高める. 脂肪と肥満に関連したタンパク質 (FTO) は,このm6Amマークを逆転させ,mRNAの運命を影響します.

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