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Updated: Mar 9, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
09:58

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts

Published on: February 24, 2015

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3-トリフロキシヤリンの [2+2] サイクルダクトからのグロブ断片化による選択的アリン形成

Jiarong Shi1, Hai Xu1, Dachuan Qiu1

  • 1School of Chemistry and Chemical Engineering, Chongqing University , 174 Shazheng Street, Chongqing 400030, P. R. China.

Journal of the American Chemical Society
|December 31, 2016
PubMed
まとめ

新しい方法により,2+2サイクル添加に続くグロブ断片化により,2−アリン中間物質を合成することができる. このアプローチは,様々な領域の構造に対して制御された地域選択性を提供します.

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Cycloaddition Reactions: Overview01:16

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
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