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Updated: Mar 9, 2026

Assembly and Purification of Prototype Foamy Virus Intasomes
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クリオ-エム構造とHIV-1鎖移転複合体の原子モデル

Dario Oliveira Passos1, Min Li2, Renbin Yang2

  • 1Laboratory of Genetics and Helmsley Center for Genomic Medicine, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|January 7, 2017
PubMed
まとめ

研究者らは,HIV-1鎖移転複合体 (STC) の高解像度冷凍電子顕微鏡構造を明らかにした. この構造は,ヒト免疫不全ウイルス1型 (HIV-1) の共通するインタソームコアアーキテクチャが,組み立てのために異なるインテグラーゼ (IN) ドメインモジュールを収容する方法を明らかにします.

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