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Updated: Mar 8, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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マクロサイクルされた拡張ペプチド:タンキラーゼの基板認識領域を阻害する

Wenshu Xu1, Yu Heng Lau2, Gerhard Fischer3

  • 1Department of Pharmacology, University of Cambridge , Tennis Court Road, Cambridge CB2 1PD, United Kingdom.

Journal of the American Chemical Society
|January 14, 2017
PubMed
まとめ

研究者は,タンキラーゼタンパク質 (TNKS) を標的とするペプチド阻害剤を作成するための新しいダブルクリックマクロサイクライゼーション方法を開発しました. これらの阻害剤は,従来のPARP阻害剤の毒性なしにWntシグナル伝達を妨害することで,がん治療の有望性を示しています.

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