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リガンド Sas とその受容体 PTP10D は,腫瘍抑制細胞の競争を誘発する

Masatoshi Yamamoto1, Shizue Ohsawa1, Kei Kunimasa1

  • 1Laboratory of Genetics, Graduate School of Biostudies, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

Nature
|January 17, 2017
PubMed
まとめ

正常な上皮細胞は,Sas- PTP10Dシステムによって仲介された細胞競争によって腫瘍的隣人を排除する. この相互作用はEGFRシグナル伝達を抑制し,腫瘍抑制のためのJNKシグナル伝達を促進します.

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