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Patch Clamp

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

Controlled-Potential Coulometry: Electrolytic Methods

Controlled-Potential Coulometry: Electrolytic Methods

Controlled-potential coulometry, also known as potentiostatic coulometry, employs a three-electrode system in which the working electrode's potential is precisely regulated using a potentiostat. Platinum working electrodes are utilized for positive potentials, while mercury pool electrodes are favored for extremely negative potentials. The platinum counter electrode is separated from the analyte using a membrane or salt bridge to avoid interference in the analysis.
The chosen potential...

Capillary Electrophoresis: Instrumentation

Capillary Electrophoresis: Instrumentation

Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...

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Updated: Mar 8, 2026

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

Published on: June 10, 2011

ポリエレクトロライトブラッシュ改変マイクロパイプでのマイクロメートルスケールのイオン電流補正

Xiulan He^1,2, Kailin Zhang¹, Ting Li^1,2

¹Beijing National Laboratory for Molecular Science, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, the Chinese Academy of Sciences , Beijing 100190, China.

Journal of the American Chemical Society

|January 19, 2017

まとめ

この要約は機械生成です。

研究者は,ポリミダゾリウムブラシ改造マイクロパイペットを用いてマイクロメートルスケールでイオン電流補正 (ICR) を観察した. この発見は,ICRをより大きなスケールに拡張し,デバイスの開発のための新しい可能性を提供します.

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Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

Published on: November 19, 2015

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

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Last Updated: Mar 8, 2026

Microiontophoresis and Micromanipulation for Intravital Fluorescence Imaging of the Microcirculation

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Published on: June 10, 2011

Multifunctional, Micropipette-based Method for Incorporation And Stimulation of Bacterial Mechanosensitive Ion Channels in Droplet Interface Bilayers

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A Closed-Type Wireless Nanopore Electrode for Analyzing Single Nanoparticles

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Published on: March 20, 2019

科学分野:

ナノテクノロジー
電気化学
材料科学

背景:

イオン電流補正 (ICR) は通常ナノスケールで研究されます.
マイクロパイペットは,マイクロメートルスケールで表面を操作し,機能化するためのプラットフォームを提供します.

研究の目的:

マイクロメートルスケールでのイオン電流直化 (ICR) の観測の可能性を調査する.
マイクロメートルスケールのイオン電流補正 (MICR) を理解するためのモデルを開発する.

主な方法:

ポリミダゾリウムブラシ (PimB) 改変したマイクロパイペットを対称な電解質溶液で利用する.
PoissonとNernst-Planckの方程式に基づいた有限元シミュレーションを使用しています.
インサイトコンフォカルレーザースキャニング顕微鏡

主要な成果:

マイクロメートルスケールのイオン電流補正 (MICR) が初めて実証された.
MICRの3層モデル (充電,電気二重,散発層) を提案し,検証した.
ポリマーの長さ,電解質濃度,ピペット半径を含むMICRに影響を与える重要な要因を特定した.

結論:

ICR現象をマイクロメートルスケールまで拡張しました
提案された3層モデルでは,マイクロスケールとナノスケールの両方でICRを理解するための枠組みを提供します.
PimBで改造されたマイクロパイペットは,新しいICRベースのデバイスを開発するための多用途のプラットフォームを提供します.