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Updated: Mar 8, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
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Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

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メチシリン耐性ステロコクスのペニシリン結合タンパク質2aにおけるコンフォルマショナル・ダイナミクス,アロステリック通信ネットワークおよび触媒の活性化

Kiran V Mahasenan1, Rafael Molina2, Renee Bouley1

  • 1Department of Chemistry and Biochemistry, University of Notre Dame , Notre Dame, Indiana 46556, United States.

Journal of the American Chemical Society
|January 19, 2017
PubMed
まとめ

Staphylococcus aureusのペニシリン結合タンパク質2a (PBP2a) は,ベータラクタム抗生物質に抵抗するアロステリックサイトを使用しています. このメカニズムには,活性部位を開くループの動きがあり,PBP2aが抑制を回避し,抗生物質耐性につながる.

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