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Morphogenesis02:19

Morphogenesis

30.6K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.6K
Forced Transdifferentiation01:28

Forced Transdifferentiation

2.4K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
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Gastrulation01:56

Gastrulation

68.3K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
68.3K
Cellular Differentiation00:57

Cellular Differentiation

6.0K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
6.0K
Cell Migration01:19

Cell Migration

7.1K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.1K
Cell Migration01:09

Cell Migration

19.0K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

Published on: January 30, 2014

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モルフォゲンからモルフォゲネシスへ

Darren Gilmour1, Martina Rembold2,3, Maria Leptin1,2

  • 1European Molecular Biology Laboratory, 69117 Heidelberg, Germany.

Nature
|January 20, 2017
PubMed
まとめ
この要約は機械生成です。

科学者は 細胞の運命を制御する遺伝子を 細胞の機械と結びつけることで ゲノムがどのように 生物の形状を決定するかを発見しています この研究は 遺伝子型-フェノタイプのギャップを埋め,強固な臓器組立と組織工学の理解を進める.

さらに関連する動画

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

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Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
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Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy
09:16

Analyzing Craniofacial Morphogenesis in Zebrafish Using 4D Confocal Microscopy

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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

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Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
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科学分野:

  • 発達生物学
  • ゲノミクス
  • バイオ物理学

背景:

  • 生物の形状におけるゲノムの役割を理解することは,生命科学の重要な目標です.
  • ゲノタイプとフェノタイプの間のギャップを埋めるには,細胞の運命を遺伝的に制御し,細胞の形状を生成するメカニズムと結びつける必要がある.

研究 の 目的:

  • 細胞の運命を制御する遺伝子と 形を生成する細胞機械の間の 機械的リンクを特定する.
  • 形状制御の異なるレベルを統合する論理とメカニズムを明らかにする.
  • 組織工学の枠組みを提供するのは,形態変異の包括的な理解に基づいています.

主な方法:

  • 細胞の運命を決定する 遺伝子の制御を調査する
  • 生物学的な形を作り出す 細胞機械を分析する
  • 臓器組立におけるクロストークとフィードバックのメカニズムを研究する.

主要な成果:

  • 遺伝子と細胞の形状の生成の間のメカニズム的なリンクが特定されています.
  • 統合ロジックと形状制御のメカニズムが生まれています.
  • クロス・トークとフィードバック・メカニズムは 臓器組立の強さを高めます

結論:

  • モルフォゲネシスの"完全な循環"の理解が生まれている.
  • この理解は生物学における 重要なパズルを解決します
  • この発見は将来の組織工学のアプローチの枠組みを提供する.