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Updated: Mar 8, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes
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酵素触媒におけるダイマー非対称性とプロトマーダイナミクスの役割

Tae Hun Kim1, Pedram Mehrabi2,3, Zhong Ren4,5

  • 1Department of Chemistry, University of Toronto, Mississauga, Ontario L5L 1C6, Canada.

Science (New York, N.Y.)
|January 21, 2017
PubMed
まとめ

この研究では,フッ素酸脱酸化酵素 (FAcD) がダイナミックな非対称性およびアロステル経路を使用して基質を効率的に結合し,反応を触媒化する方法を明らかにしました. 強化された形状交換と水分放出は,細菌酵素におけるその機能の鍵です.

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