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Updated: Mar 8, 2026

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
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トランスクリプション・ファクターの協同結合が再プログラミングをオーケストラ化

Constantinos Chronis1, Petko Fiziev1, Bernadett Papp1

  • 1David Geffen School of Medicine, Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Bioinformatics Program, Los Angeles, CA 90095, USA.

Cell
|January 24, 2017
PubMed
まとめ

Oct4,Sox2,Klf4,cMyc (OSKM) は,体性増強剤を無効化し,増強剤を選択することによって,細胞を多能性へと再プログラムする. これらのプロセスは,ステージ固有の転写因子とのOSKM相互作用によって導かれます.

キーワード:
クリフ4オクト4ソックス2コラボレーション・バインディング強化剤誘導された多能幹細胞プラリポテンシー再プログラム転写因子

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