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Updated: Mar 8, 2026

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells
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TGF-βの活性化において,力はマクロ分子構造と相互作用する

Xianchi Dong1, Bo Zhao1, Roxana E Iacob2

  • 1Children's Hospital Boston and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|January 25, 2017
PubMed
まとめ

αVβ6のようなインテグリンは,プロ-TGF-β1に結合し,力を加えることで細胞外マトリックスを再構成する. この結合は特定の方向性を安定させ,成長因子放出のための力伝達を可能にします.

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