ニトリルテンプレートによるRh (III) -触媒化メタ-C-Hオレフィネーション
Hua-Jin Xu1, Yi Lu1, Marcus E Farmer2
1Coordination Chemistry Institute, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing National Laboratory of Microstructures, Collaborative Innovation Center of Advanced Microstructures, Nanjing University , Nanjing 210023, China.
Journal of the American Chemical Society
|January 28, 2017
まとめ
この研究では,ロジウム (III) 触媒によるリモートメタ-C-H活性化のための新しいU形ナトリルテンプレートを導入し,C-H機能化の以前の制限を克服しました. この画期的な発見は,高度な触媒システムの開発に新しい道を開きます.
科学分野:
- 有機金属化学
- カタリシス
- 有機合成
背景:
- ロジウム (III) 触媒によるオーソ-C-H機能化は確立されている.
- 遠隔C-H機能化は,大きなリングの中間体によって未熟のままである.
- 既存の方法は,Rh (III) を用いたメタ-C-H活性化のための戦略を欠いている.
研究 の 目的:
- Rh (III) 触媒による遠隔メタ-C-H活性化の最初の例を報告する.
- この反応性を指示する際にU形のニトリルテンプレートの有用性を実証する.
- 大環ロダサイクルの中間物質の形成を調査する.
主な方法:
- 指示模板としてU形のニトリルを使用した.
- C−H活性化のためのロジウム (III) 触媒を用いる.
- 12基のマクロサイクル中間経路を仮定した.
主要な成果:
- 遠隔メタC-H活性化が成功しました.
- U型ナトリルの方向性を証明した.
- 触媒サイクルにおけるマクロサイクル中間物質の証拠を提供した.
結論:
- U型ニトリルテンプレートは,Rh (III) 触媒による新しいリモートメタ-C-H活性化を可能にします.
- この研究は,C−H機能化反応の範囲を拡大する.
- Rh (III) 触媒によるメタ-C-H活性化におけるリガンド設計の機会を強調し,Pd (II) 触媒とは異なる.
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