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ガンマ振動は上から下へと信号を送り 食物探求を可能にします
Marta Carus-Cadavieco1, Maria Gorbati1, Li Ye2,3
1Behavioural Neurodynamics Group, Leibniz Institute for Molecular Pharmacology (FMP)/ NeuroCure Cluster of Excellence, Berlin, Germany.
Nature
|February 2, 2017
まとめ
マウスの脳のガンマ振動が 食物探求の行動を調整します この上から下への経路は 栄養を調節する 神経活動を同期させ 摂食障害の洞察力を提供します
科学分野:
- 神経科学
- 行動神経科学
- 計算神経科学
背景:
- 動物と人間は生理的な必要性とは無関係に報酬を追求し,代謝の要求から分離した食物探しの行動で示される.
- この解離は 摂食障害の難しい症状であり 摂食の認知制御を理解する必要性を強調しています
- 視床下部と横隔膜は 皮質ネットワークからの入力を受け取り 栄養の鍵ですが 認知制御のメカニズムは不明です
研究 の 目的:
- 食物探求行動の 認知制御の基礎にある 神経機構を調査する
- ガンマ振動が餌に関する行動の組織化における役割を決定する.
- 給食中の下垂体活動を制御する上から下の経路を特定する.
主な方法:
- マウスの側下垂体と上流領域におけるガンマ振動 (30〜90 Hz) の電気生理学的記録.
- 側隔膜と前頭前皮質の操作です
- 食事探求と食事摂取に関する行動分析
主要な成果:
- 側下垂体と上流領域の 協調されたガンマ振動が 食物探求の行動を組織します
- ソマトスタチン陽性側隔膜細胞からのガンマリズム入力が,摂取ではなく,食物へのアプローチを促進します.
- 側隔膜への中部前頭皮質の投影はガンマリズム入力を提供し,食物報酬による学習の改善と因果的に関連しています.
結論:
- ガンマ同期を利用した上から下への経路は,下垂体ニューロンの活動を動的に再構成することによって,食事の行動を調節します.
- この経路は皮質下ネットワークの活動を誘導し 食事に対する認知制御の 潜在的メカニズムを提供します
- この発見は 報酬を求める神経の基礎と 摂食障害における 制御不全について 洞察力を与えてくれます
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