Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

670
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
670
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

1.0K
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
1.0K
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

1.4K
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.4K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

633
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
633
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

76
Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
76

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Longitudinal Changes in Coronary Artery Calcium Distribution and Atherosclerotic Cardiovascular Disease Risk.

Journal of the American Heart Association·2026
Same author

Gaps in lipid screening and statin use among uninsured patients in a charitable community clinic.

American journal of preventive cardiology·2026
Same author

Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology.

Journal of the American College of Cardiology·2026
Same author

Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology.

Circulation·2026
Same author

The association between alcohol consumption and inflammatory biomarkers in a large, diverse, community-based sample.

Alcohol and alcoholism (Oxford, Oxfordshire)·2026
Same author

Advancing Women's Health Through Public Policy.

Circulation·2026

関連する実験動画

Updated: Mar 8, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

13.0K

性別による心臓代謝バイオマーカーの違い

Jeanney Lew1, Monika Sanghavi1, Colby R Ayers1

  • 1From Departments of Medicine (J.L., M.S., D.K.M., M.O.G., I.N., J.D.B., A.K., A.R., J.A.d.L.) and Clinical Sciences (C.R.A., D.K.M., J.D.B.), UT Southwestern Medical Center, Dallas, TX; Division of Medicine, Akershus University Hospital, Lørenskog, and University of Oslo, Norway (T.O.); Department of Clinical Pharmacology and Toxicology, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany (D.A.); and Department of Cardiovascular Medicine, University of Oxford, United Kingdom (D.A.).

Circulation
|February 4, 2017
PubMed
まとめ

心血管疾患 (CVD) のバイオマーカープロファイルは,男性と女性の間で有意に異なります. 性別によるこれらの差異は,肥満,内皮機能障害,炎症,心臓ストレスに関連するバイオマーカーで最も顕著であり,CVDの発達に関するさらなる調査を正当化しています.

キーワード:
バイオマーカー体の構成心血管疾患閉経セックス女性

さらに関連する動画

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

11.2K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.6K

関連する実験動画

Last Updated: Mar 8, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
09:29

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

13.0K
An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
10:31

An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment

Published on: April 20, 2018

11.2K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.6K

科学分野:

  • 心血管医学
  • バイオマーカーの研究
  • 健康 に 関する 性別 の 違い

背景:

  • 心血管疾患 (CVD) のバイオマーカープロフィールを一般集団で比較するデータは限られている.
  • 性別に基づくバイオマーカーの違いを理解することは,パーソナライズされたCVDリスク評価と管理に不可欠です.
  • 以前の研究では,異なる病理生理学的経路における複数のバイオマーカーカテゴリを包括的に分析していなかった.

研究 の 目的:

  • 異なる病理生理学的経路を反映した幅広いバイオマーカーの性差を分析する.
  • CVDリスク要因,体組成,心臓の形状などの混同要因を比較する.
  • 性別による大きな差異を示す特定のバイオマーカーを特定する.

主な方法:

  • 多民族集団を対象とした ダラス・ハート・スタディの横断分析です
  • 性別と30の異なるバイオマーカーの関連性を6つの病理学的カテゴリーで評価
  • 多変量線形回帰モデルでは,年齢,人種,CVDリスク因子,腎機能,インスリン抵抗性,体質,心臓形態が調整されました.

主要な成果:

  • 脂質,アディポキン,炎症,内皮機能障害,筋細胞損傷/ストレス,腎機能を含む複数のバイオマーカーカテゴリーにおいて,有意な性差が観察されました.
  • 女性ではHDLコレステロール,レプチン,d- ダイマー,NT- プロBNPのレベルが高く,男性ではLDLコレステロール,アディポネクチン,hs- トロポニンTのレベルが高かった.
  • 調整されたモデルでは,肥満,内皮機能,炎症,心臓のストレスに関連するバイオマーカーの性別のパターンが明らかになった.

結論:

  • バイオマーカーのプロフィールでは,一般的な集団における 性別による有意な差異が示されています.
  • これらの違いは特に肥満,内皮機能障害,炎症性細胞徴募,心臓のストレス/傷害に関連するバイオマーカーで顕著です.
  • バイオマーカーで定義されたこれらの病理生理学的プロセスが,CVDの発達と結果における性差に寄与するかどうかを判断するには,さらなる研究が必要である.