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Visualization of DNA Repair Proteins Interaction by Immunofluorescence
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DNA-PKcs構造は,DNAの二重鎖の断裂修復を調節するアロステリックメカニズムを示唆する

Bancinyane L Sibanda1, Dimitri Y Chirgadze1, David B Ascher1

  • 1Department of Biochemistry, University of Cambridge, Old Addenbrooke's Site, 80 Tennis Court Road, Cambridge CB2 1GA, UK.

Science (New York, N.Y.)
|February 4, 2017
PubMed
まとめ

DNA依存タンパク質キナーゼ触媒子ユニット (DNA-PKcs) は,DNAの二重鎖の断裂を修復する. その構造は,アロステル活性化メカニズムとBRCA1との競争を明らかにし,DNA修復経路の選択に影響を与えます.

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