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関連する概念動画

Multiple Allele Traits01:49

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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

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Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
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Translation01:31

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Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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シークル細胞病

Russell E Ware1, Mariane de Montalembert2, Léon Tshilolo3

  • 1Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Lancet (London, England)
|February 5, 2017
PubMed
まとめ
この要約は機械生成です。

シークル細胞病は 異常な赤血球が血流を阻害するので 激しい痛みと臓器損傷を引き起こします 新しい遺伝子治療は 改善された診断と管理戦略と共に 治療への希望をもたらします

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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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科学分野:

  • 血液学
  • 遺伝学
  • 血管生物学

背景:

  • シークル細胞病 (Sickle cell disease,SCD) は,世界中で何百万もの患者を抱える,生命を脅かす血液学的疾患です.
  • 異常な赤血球が血管閉塞を引き起こし 組織不血症,炎症,急性痛風を引き起こします
  • 慢性臓器損傷と早期の死亡は 繰り返し発生する状血症と 血液溶解性貧血によるものです

研究 の 目的:

  • 状細胞疾患の現在の治療戦略と新たな治療戦略を 検討する.
  • 診断と病気管理の最近の進歩を強調する.
  • SCDの病理生理学と治療における現在進行中の論争に対処するために.

主な方法:

  • 状細胞疾患における現在の治療法と進行中の研究の文献レビュー.
  • スクリーニング,診断,管理の最近の進歩の分析.
  • SCDにおける論争の的側面の議論

主要な成果:

  • 現在の治療には輸血とヒドロキシカルバミドが含まれます.幹細胞移植は治療の可能性があります.
  • 新興治療には遺伝子治療と遺伝子編集が含まれます
  • 最近の進歩には 普遍的な脳卒中リスクスクリーニング, 鉄過量管理の改善, 診療所の診断が含まれています

結論:

  • 状細胞疾患の管理には大きな進展があり,新たな治療法が目前に迫っています.
  • 病理生理学と管理における論争を解決することは 患者の成果を改善するために不可欠です
  • SCDの治療の将来は 先進的な治療法と診断と 総合的なケアを組み合わせるものです