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発現したタンパク質結合と生物結合のためのセレノシステインの使用

Jun Liu1, Qingqing Chen1, Sharon Rozovsky1

  • 1Department of Chemistry & Biochemistry, University of Delaware , Newark, Delaware 19716, United States.

Journal of the American Chemical Society
|February 11, 2017
PubMed
まとめ

この研究では,セレノシステイン媒介の結合により,異質的に発現したタンパク質の断片を用いたタンパク質工学の新しい方法が導入されています. このアプローチは,以前の制限を克服し,タンパク質の改変とエスカフォードの設計においてより大きな柔軟性を可能にします.

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What is Gene Expression?

Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
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mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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Regulation of Expression Occurs at Multiple Steps

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