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Updated: Mar 7, 2026

Study of Protein-protein Interactions in Autophagy Research
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KICSTORはGATOR1をリソソームに誘導し,mTORC1を調節する栄養素に必要である

Rachel L Wolfson1,2,3,4, Lynne Chantranupong1,2,3,4, Gregory A Wyant1,2,3,4

  • 1Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Nature
|February 16, 2017
PubMed
まとめ

新しく特定されたKICSTORタンパク質複合体は,ラパミシン複合体1 (mTORC1) の信号伝達のメカニズムを否定的に調節する. この複合体は,栄養不足への反応としてmTORC1を阻害するために不可欠であり,その機能不全は神経疾患に関連しています.

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