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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation
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Genome-wide Analysis of HDAC Inhibitor-mediated Modulation of microRNAs and mRNAs in B Cells Induced to Undergo Class-switch DNA Recombination and Plasma Cell Differentiation

Published on: September 20, 2017

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B細胞のゲノム不安定性を増加させる

Mara Compagno1, Qi Wang1, Chiara Pighi1

  • 1Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, Massachusetts 02115, USA.

Nature
|February 16, 2017
PubMed
まとめ

PI3Kδ経路を標的とする特定の白血病およびリンパ腫薬は,活性化誘発型シチジンデアミナーゼ (AID) の発現を強めることで,B細胞のゲノム不安定性を高めます. このAIDに依存するメカニズムは,突然変異と転移の頻度を高め,長期的な患者の安全性に影響を与える可能性があります.

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