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Updated: Mar 7, 2026

Targeting Cysteine Thiols for in Vitro Site-specific Glycosylation of Recombinant Proteins
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アスパルテート・グリコシレーションはアイソアスパルテートへのイソメリゼーションを誘発する

John Janetzko1,2, Suzanne Walker2

  • 1Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.

Journal of the American Chemical Society
|February 17, 2017
PubMed
まとめ

O- リンクされたβ- N- アセチルグルコサミントランスファーゼ (OGT) 酵素は,アスパルテート残基を素早くグリコシラートし,タンパク質イソメリゼーションにつながる中間物質を形成します. これは,OGTが細胞内のアスパルト酸からアイソアスパルト酸への変換を酵素的に触媒化することを示唆している.

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